46EFFECT OF PAROXETINE ON RATS USING ACUTE WOUND HEALING MODELTo evaluate the wound healing activity of Paroxetine in dead space wound model and to study its effects on Dexamethasone suppressed wound healing. Methods: For assessment of wound healing activity dead space wound model was used. Group I received distilled water, orally, Group II received Paroxetine, i.p, Group III received Dexamethasone intramuscularly [i.m] and Group IV received Dexamethasone i.m and Paroxetine, i.p. Parameters observed were dry weight and hydroxyproline content in dead space wound model. Results: In the dead space model, there was increase in the collagen content of the granulation tissue, which was statistically higher in paroxetine group [P=0.002] when compared to control group. Those rats which received Dexamethasone + paroxetine did not show any significant change in the collagen content when compared to rats which received Dexamethasone alone. Conclusion: Granulation tissue showed higher collagen content in paroxetine group when compared to control group. Paroxetine may be an effective agent for healing wounds.dwajani@gmail.comResearch422014Paroxetine,Dexamethasone,Dead space,RatsDwajani S,Pavan Kumar KVDepartment of Pharmacology, St.John’s Medical College and Hospital, Bangalore – 34, Karnataka, India.,Department of Pharmacology, St.John’s Medical College and Hospital, Bangalore – 34, Karnataka, India.