23A REVIEW ON HISTORY OF CAFFEINECaffeine is a bitter, white crystalline xanthine alkaloid that acts as a stimulant drug. Caffeine is found in varying quantities in the seeds, leaves, and fruit of some plants, where it acts as a natural pesticide that paralyzes and kills certain insects feeding on the plants, as well as enhancing the reward memory of pollinators. It is most commonly consumed by humans in infusions extracted from the seed of the coffee plant and the leaves of the tea bush, as well as from various foods and drinks containing products derived from the kola nut. This review discussed on pharmacological & physiological effects, toxicity and adverse effects of Caffeine.bala.hospira@gmail.comReview312013Caffeine,Mechanism,Adverse EffectG. Balammal,N.S. Midhuna Sagari,B.S. Manoj Kumar,P. Jayachandra ReddyDepartment of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati, Andhra Pradesh – 517 501, India.,Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati, Andhra Pradesh – 517 501, India.,Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati, Andhra Pradesh – 517 501, India.,Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati, Andhra Pradesh – 517 501, India.