138PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF COLDENIA PROCUMBENS AS A NATURAL ANTI-OBESITY AGENTObesity and hyperlipidemia are global health concerns linked to cardiovascular and metabolic diseases. This study investigates the anti-obesity and antihyperlipidemic potential of Methanol Extract (MECP) and Aqueous Extract (AECP) of Coldenia procumbens in high-fat diet-induced obese Wistar rats. Preliminary phytochemical screening revealed the presence of phenolic compounds, flavonoids, and triterpenoids, contributing to the observed therapeutic effects. Acute toxicity studies showed no adverse effects, confirming the safety of both extracts at 2000 mg/kg. The extracts, particularly MECP at 500 mg/kg, significantly reduced body weight, Body Mass Index (BMI), and lipid profiles, including total cholesterol, triglycerides, LDL, and VLDL levels, while enhancing HDL levels. Additionally, antioxidant enzyme levels (SOD, catalase, glutathione peroxidase) improved, suggesting antioxidative activity that mitigates obesity-induced oxidative stress. Histopathological analysis supported these findings, showing regenerative effects in adipose tissue. The study demonstrates the efficacy of Coldenia procumbens extracts in managing obesity and dyslipidemia, providing a foundation for future research on plantbased anti-obesity agentsjothies82@gmail.comResearch1412024Coldenia Procumbens, Obesity, Antihyperlipidemic, Antioxidant, Lipid Metabolism, Wistar ratsr. Jothieswari D, Vamsi Kumar S.AProfessor and Principal, Sri Venkateswara College of Pharmacy, RVS Nagar, Chittoor, Andra Pradesh, India, Sri Venkateswara College of Pharmacy, RVS Nagar, Chittoor, Andra Pradesh, India