NOOTROPIC EFFECT OF LEAF EXTRACT OF SORGHUM VULGARE L. ON SCOPOLAMINE INDUCED AMNESIC MICE

A. Zechariah Jebakumar
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Hassan S. Nondo
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Siju K. George
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
G.Manoj
Dept of Pharmacology, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai - 600096, India

Antidiarrhoeal activity ,Randia uliginosa ,Traditional medicine ,Castor oil induced diarrhoea ,Enteropooling method ,

Objective of this study was to evaluate the nootropic activity of methanolic extract of leaves of Sorghum vulgare (L.) (MESV) using scopolamine induced amnesia in mice on Morris water maze and Elevated plus maze. MESV (200 & 400mg/kg) was administered orally for seven successive days followed by Scopolamine (0.4 mg/kg i.p.) on 8th day in mice. Morris water maze and Elevated plus maze was employed to evaluate learning and memory. Scopolamine was used to induce amnesia in mice and the activity was compared with standard drug Piracetam. MESV significantly improved learning and memory in mice and reversed the scopolamine induced amnesia. The MESV afforded significant neuroprotection against using scopolamine induced amnesia in mice.

6 , 1 , 2016