Pharmacologival evaluation of anti-arthritic potential of momordica cymbalaria

A. Zechariah Jebakumar
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Hassan S. Nondo
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Siju K. George
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
G.Manoj
Dept of Pharmacology, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai - 600096, India

Antidiarrhoeal activity ,Randia uliginosa ,Traditional medicine ,Castor oil induced diarrhoea ,Enteropooling method ,

ABSTRACT Momordica cymbalaria (Cucurbitaceae) is a plant, reported for its variety of ethnic medicinal uses. Hence we have planned to screen anti arthritic activity of fruit of the plant with the alcoholic and aqueous extracts. Fruit powder successively extracted with alcohol and water were subjected for Phytochemical screening to identify different phytoconstituents. LD50 studies for both (alcoholic and aqueous) extracts were conducted up to the dose level of 2 g /kg by following OECD up and down method of guidelines No.425.Anti-arthritic activity in Formaldehyde, Freund’s adjuvant induced arthritis in rats and Collagen induced arthritis model in mice.

5 , 1 , 2015