INTRODUCTION TO DRUG-MODULATION OF HORMONAL PATHWAYS IN ENDOCRINE PHARMACOLOGY
A. Zechariah Jebakumar
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Hassan S. Nondo
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Siju K. George
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
G.Manoj
Dept of Pharmacology, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai - 600096, India
The hormonal pathway drug modulation is a fundamental principle of endocrine pharmacology, which has provided the field with therapeutic solutions in terms of a broad variety of hormonal disorders and endocrine ailments. These illnesses which contain diabetes, thyroid illnesses, reproductive malfunctions and hormone delicate cancers are frequently treated by medications that interact directly with the hormonal routes, e.g. hormone substitution medications, receptor modulators and enzyme inhibitors. Treatment of the endocrine system with the help of pharmacological means makes it possible to regulate it and, in such a way, increase the therapeutic effect and reduce the side effects. The recent developments in the area of designing drugs, personalized medicine, and biotechnology have offered new approaches to controlling the action of hormones more precisely and there is hope that more effective therapies with fewer side effects are achieved. This review examines the different methods of drug-modulation of the hormonal pathways, such as receptor-based therapy, enzyme inhibitors and gene editing technologies, whilst also addressing some of the difficulties with drug resistance, and environmental effects to hormone function. These mechanisms require further knowledge to further the endocrine pharmacology and patient outcomes of endocrine disorders treatment
16 , 1 , 2026
32 - 38