PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF COLDENIA PROCUMBENS AS A NATURAL ANTI-OBESITY AGENT
A. Zechariah Jebakumar
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Hassan S. Nondo
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Siju K. George
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
G.Manoj
Dept of Pharmacology, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai - 600096, India
Obesity and hyperlipidemia are global health concerns linked to cardiovascular and metabolic diseases. This study investigates the anti-obesity and antihyperlipidemic potential of Methanol Extract (MECP) and Aqueous Extract (AECP) of Coldenia procumbens in high-fat diet-induced obese Wistar rats. Preliminary phytochemical screening revealed the presence of phenolic compounds, flavonoids, and triterpenoids, contributing to the observed therapeutic effects. Acute toxicity studies showed no adverse effects, confirming the safety of both extracts at 2000 mg/kg. The extracts, particularly MECP at 500 mg/kg, significantly reduced body weight, Body Mass Index (BMI), and lipid profiles, including total cholesterol, triglycerides, LDL, and VLDL levels, while enhancing HDL levels. Additionally, antioxidant enzyme levels (SOD, catalase, glutathione peroxidase) improved, suggesting antioxidative activity that mitigates obesity-induced oxidative stress. Histopathological analysis supported these findings, showing regenerative effects in adipose tissue. The study demonstrates the efficacy of Coldenia procumbens extracts in managing obesity and dyslipidemia, providing a foundation for future research on plantbased anti-obesity agents
14 , 1 , 2024
16 - 25