DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NEWER CHROMAN-4-ONE DERIVATIVES

A. Zechariah Jebakumar
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Hassan S. Nondo
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Siju K. George
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
G.Manoj
Dept of Pharmacology, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai - 600096, India

Antidiarrhoeal activity ,Randia uliginosa ,Traditional medicine ,Castor oil induced diarrhoea ,Enteropooling method ,

The series consist of total 18 numbers of compounds with well defined monoamine oxidase-B inhibitory activity. The series (E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidaseB inhibitors have been chosen for study. The IC5o values were chosen for generating common pharmacophore hypotheses and 3D- QSAR study. In the „Score Hypotheses? step, common pharmacophores were examined, and a scoring procedure was applied to identify the pharmacophore from the best alignment of the chosen actives and provided a ranking of the different hypotheses for the next step

13 , 2 , 2023