DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NOVEL ?- CARBOLINE DERIVATIVES

A. Zechariah Jebakumar
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Hassan S. Nondo
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Siju K. George
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
G.Manoj
Dept of Pharmacology, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai - 600096, India

Antidiarrhoeal activity ,Randia uliginosa ,Traditional medicine ,Castor oil induced diarrhoea ,Enteropooling method ,

A series of 51 compounds [N-(substituted-benzylidene)-?-carboline-3-carbohydrazide derivatives (Barbosa et al., 2011)] having significant inhibitory activity against cancer cell lines was selected and the presented biological activity (in micromolar concentration) of those compounds were conveniently converted into Log (1/IC50) values (molar) for carrying out QSAR analysis against anti-cancer activities using Chemoffice Ultra version 7.0.1, from Cambridge software corporation. The values of related parameters of all the molecules were calculated after effective energy minimization through MM2, MOPAC force fields provided by Chem3D Ultra 7.0.1

13 , 1 , 2023