Malaria continues to be a cause of high mortality and morbidity, especially in region which endemic for malaria. Malaria infection associated with many changes in blood parameters which include platelets count, in the current study the platelet count were evaluated in case of malaria positive samples. The study was include 100 malaria positive patients and 10 malaria negative individuals, all participants were checked for platelets count and the parasite species and parasitaemia were determined for all malaria positive patients. There were 76% of malaria infected patients had thrombocytopenia, the result show statistical correlation between malaria and thrombocytopenia, no correlation between thrombocytopenia and plasmodium species or parasitaemia. A finding of thrombocytopenia should increase the suspicion of malaria infection.