The main objectives of this study is to Screen the bioactive guided fractions of Caesalpinia crista for its antioxidant and antiurolithiatic potency. Based on preliminary phytochemical tests, ethanolic extract was tested for antioxidant efficacy by DPPH Radical Scavenging assay and antiurolitiathic potentials on male Wistar albino rats by administering ethylene glycol (0.75% v/v) by oral route. Urine and blood serum was collected from all the tested animals and analyzed for the presence of calcium, oxalate. Antioxidant assay has revealed that the tested fractions were equally potent as that of the standard drugs (Ascorbic acid). The treatment with ethanol fractions significantly decreased the calcium levels in experimental rats (p<0.001). The urine analysis has also revealed significant (p<0.001) reduction in crystal size in the treated rats. The fractions (ethanol) have shown significant antioxidant effect along with the Antiurolithiatic potency by reducing calculi through different pathways along with mild diuretic activity