This study aimed to evaluate the effectiveness of using the Virtual Ophthalmology Clinic (VOC) as a learning tool for improving patient history-taking skills among medical students. A total of 188 medical students were randomly assigned to either an experimental or control group in a randomized controlled trial. Both groups underwent pre- and post-tests, as well as a satisfaction survey, with long-term retention rates assessed afterward. Results indicated a significant improvement in correct answers for both experimental and control groups from pre- to post-rotation. However, the experimental group showed a significantly greater improvement compared to the control group. On average, the experimental group scored 1.6 points higher (representing an 8% improvement) than the control group after 12 months. The findings suggest that incorporating VOC into medical education can lead to enhanced academic performance and address challenges in ophthalmic learning outcomes within a crowded medical curriculum