This study evaluated the anti-anxiety and antidepressant activities of the in mice. We found that administration of 400 μg/kg Hibiscus rosa sinensis or 200 mg/kg DZP for 7 days significantly reduced the immobility time in FST. These results provide support for the potential anti-anxiety and antidepressant activity of Hibiscus rosa sinensis and contribute towards validation of the traditional use of Hibiscus rosa sinensis in the treatment of emotional disorders.In this study, elevated plus maze test were used to evaluate the anti-anxiety and ani depressant activity of extract Hibiscus rosa sinensis of in albino mice. The elevated plus maze is considered to be an etiologically valid animal model of anxiety. In the elevated plus maze, the open arms are more fear provoking than the closed arms. The reduction in entry and time spent in open arms are the indications of the high level of fear or anxiety. The number of entries and time spent in the open arms have been found to be increased by anxiolytics and reduced by anxiogenic agents. A significant increase in the time spent in open arms was observed after treatment with all two doses of drug. A significant increase in both time spent in open arms and the entry into open arms is observed after treatment Hibiscus rosa sinensis extract.