A transdermal drug delivery device, which may be of an active or a passive design, is a device which provides an alternative route for administering medication. These devices allow for pharmaceuticals to be delivered across the skin barrier. A drug is applied in a relatively high dosage to the inside of a patch, which is worn on the skin for an extended period of time. Through a diffusion process, the drug enters the blood stream directly through the skin. The present study was designed to develop a suitable matrix type transdermal drug delivery systems of Eletriptan using two different polymeric combinations, E RS100 and HPMC E 15; E RL 100 with HPMC E 15. E RL100 and E RS 100 are acrylic acid matrices which have been used to make drug-polymer matrix films for transdermal delivery systems which are reported as compatible with many drugs. Penetration enhancers that alter the partitioning can be useful to enhance the drug permeation. In this study various penetration enhancers Oleic acid and were used in different concentrations to determine their effect on permeation of drug.