Though the concept of gastric secretion, food digestion, acid in gastric juice, hyperacidity and gastric ulcers are known from the 17th century, the treatment of peptic ulcer is still inappropriate. Some cases of gastric ulcer demand surgical approaches. With medical advances, anti-secretory antiulcer and mucoprotective drugs are introduced. In the 19th century, with the established H. Pylori mediated pathophysiology, it had demanded the inclusion of antibiotic therapy regimens. However, the relapses, recurrences, side effects and more pronounced drug interactions of the drugs had widened the opportunity to explore medicinal plants having antiulcer activity. This present review article will cover the etiology, pathology of peptic ulcer, allopathic antiulcer drugs, their disadvantages and a view of antiulcer medicinal plants