The term Progeria is derived from the Greek word geras, meaning old age and Latin meaning of Progeria is being prematurely old. The disease involves premature aging, generally leading to death due to myocardial infarction or stroke. The disorder has a very low incidence and occurs in one per four million live births. Those born with Progeria typically live about thirteen years, although many have been known to live into their late teens and early twenties. Progeria shows characteristic facial appearance including prominent eyes, thin nose with a beaked tip, thin lips, a small chin, and protruding ears, severe hardening of the arteries beginning in childhood. The main clinical and radiological features include alopecia, thin skin hypoplasia of nails, loss of subcutaneous fat, and osteolysis. Intelligence is not impaired. Early death is caused by atherosclerosis. Transmission is most likely from a sporadic autosomal dominant mutation. Clinical manifestations are evident by the first or second year of life and include the physical characteristics usually associated with the elderly. Mentally, patients are alert and attentive with normal intelligence and emotions. Histopathologic changes occur primarily in the skin, bone, and cardiovascular tissues, while other organs appear to be unaffected. Laboratory findings are unremarkable, with the exception of an increased urinary excretion of hyaluronic acid. Death results from cardiovascular abnormalities in the majority of cases and usually occurs between the ages of 10 and 15 years