ANTI-DIARRHOEAL ACTIVITY OF RANDIA ULIGNIOSA DC IN EXPERIMENTAL ANIMALS.
A. Zechariah Jebakumar
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Hassan S. Nondo
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Siju K. George
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
G.Manoj
Dept of Pharmacology, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai - 600096, India
The present study was to scientifically evaluate anti-diarrhoeal effects of ethanolic (90%) extract of dried fruits of Randia uliginosa DC (EERU) was studied against castor oil-induced-diarrhoea model in rats. The weight and volume of intestinal content induced by castor oil were studied by enteropooling method. Standard drug atropine (3mg/kg, i.p) showed significant reductions in fecal output and frequency of droppings whereas EERU at the doses of 100 and 200 mg/kg i.p significantly retarded the castor-oil induced enteropooling and intestinal transit. The gastrointestinal transit rate was expressed as the percentage of the longest distance travelled by the charcoal divided by the total length of the small intestine. EERU at the doses of 100 and 200 mg/kg significantly inhibited (P<0.001) weight and volume of intestinal content. The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrheal agent.
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