MEMORY ENHANCING ACTIVITY OF AGERATUM CONYZOIDES L. ON CORTICOSTERONE INDUCED DEMENTIA IN MICE

A. Zechariah Jebakumar
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Hassan S. Nondo
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Siju K. George
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
G.Manoj
Dept of Pharmacology, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai - 600096, India

Antidiarrhoeal activity ,Randia uliginosa ,Traditional medicine ,Castor oil induced diarrhoea ,Enteropooling method ,

The present study was undertaken to investigate the effects of Ageratum conyzoides L. on learning and memory in mice. Morris water maze and passive avoidance paradigm were employed to test learning and memory. Two doses (100 and 200mg/kg, p.o.) of methanolic extract were administered for 21 successive days in separate group of animals. The dose of 200 & 400‐mg/kg p.o. of MEAC significantly improved learning and memory of mice in dose dependent manner. Furthermore, this dose significantly reversed the amnesia induced by Corticosterone (5 mg/kg, s.c) induced amnesia. Hence Ageratum conyzoides L. appears to be a promising candidate for improving memory and it would be worthwhile to explore the potential of this plant in the management of dementia and Alzheimer’s disease. However, further studies are necessitated to identify the exact mechanism of action.

2 , 2 , 2012