EVALUATION OF ANTI - HYPER LIPIDEMIC ACTIVITY OF HYDRO ALCOHALIC EXTRCT OF Moringa oleifera SEEDS IN HIGH FAT DIET INDUCED RAT MODEL

A. Zechariah Jebakumar
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Hassan S. Nondo
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Siju K. George
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
G.Manoj
Dept of Pharmacology, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai - 600096, India

Antidiarrhoeal activity ,Randia uliginosa ,Traditional medicine ,Castor oil induced diarrhoea ,Enteropooling method ,

Hyperlipidemia is defined as increase in the lipid content in blood. Moringa oleifera, known as Horse raddish tree (Family:Moringaceae), commonly used herb in vegetable food traditionally used for anti-oxidant, cardiotonic, hypotensive, anti-inflammatory, antipyretic, hypolipidemic, bacterial skin infection and anti microbial. To investigate effect of ethanolic extract of Moringa oleifera Seeds on triton induced hyperlipidmc rats and high cholesterol fed diet rats. Triton induced hyperlipidmc rats and High cholesterol fed diet rats exhibited significant increase in total serum cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein and significant decrease in high density lipoproteins. Treatment with ethanolic extract of Moringa oleifera Seeds significantly decreased total serum cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein and increased in high density lipoproteins in rats. Ethanolic extract of M. oleifera 300mg/kg have Hypolipidemic activity attributed due to presence of active constituents.

2 , 2 , 2012