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IJPSM JOURNAL
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Issn  2249-7579
e Issn  2249-7579
Publisher JOURNAL OF PHARMACEUTICAL BIOLOGY

EFFECT OF SHILAJIT AND PIRACETAM ON SCOPOLAMINE INDUCED EXPERIMENTAL AMNESIA IN MICE

A. Zechariah Jebakumar
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Hassan S. Nondo
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
Siju K. George
Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.
G.Manoj
Dept of Pharmacology, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai - 600096, India

Antidiarrhoeal activity ,Randia uliginosa ,Traditional medicine ,Castor oil induced diarrhoea ,Enteropooling method ,

Shilajit is a herbo-mineral drug, has been referred to as „Panacea‟, which means „a cure for all diseases‟. Piracetam is prescribed to treat amnesia, dementia, stroke, dyslexia, senility, and cognitive disorders. Scopolamine is known to produce short term amnesia in human and animals. The present study is designed to investigate the effect of Shilajit and piracetam on scopolamine induced experimental amnesia using elevated plus maze test in mice. Twelve groups of mice were employed and each group comprised of six mice. Scopolamine (0.4 mg kg-1), shilajit (100 mg kg-1), piracetam (150 mg kg-1) and distilled water (as vehicle) (10 ml kg-1) were injected intraperitoneally (ip) in different groups of mice 30 min before the training and immediate after the training. The each mouse was naïve to elevate plus maze for 90 sec. The time taken by the animals to move from the open arms to either of two sides of enclosed arms was recorded. All the results were expressed as mean±S.E.M and P<0.05 considered as statistically significant. Scopolamine treated animals exhibit significant increase in transfer latency time. On the other hand, shilajit and piracetam treated mice shown significant decrease in transfer latency time. Simultaneously, animals treated with shilajit (100 mg kg-1 i.p.) and piracetam (150 mg kg-1 i.p.) significantly exhibit decrease in transfer latency time measured after 24 hrs in the animals previously treated with scopolamine (0.4 mg kg-1 i.p.). The above observations revels that scopolamine impair learning, shilajit and piracetam improve acquisition. The results also indicates that shilajit and piracetam prevent scopolamine induce learning impairment. It may be concluded that shilajit and piracetam reverse scopolamine induced amnesia by the same mechanism i.e. improvement in cholinergic or dopaminergic activity, at least in mice species.

2 , 2 , 2012

66 - 71

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