Some hematological parameters in normal albino rats were investigated using standard laboratory techniques. The albino rats were divided into four groups (A, B, C and D) of 25 rats per group. Doses of 200 mg/kg, 400 mg/kg and 800 mg/kg of methanolic extract of Ganoderma lucidum orally administered consecutively for 21 days to rats groups A, B and C, while rats in D was administered water and served as the control group. Blood samples was weekly collected from sacrificed normal albino rats and analysed for Packed Cell Volume (PCV), red blood cell (RBC), Hemoglobin (Hb) concentrations, White Blood Cell counts (WBC) and Differential Leucocytic Counts (DLC). While haematological indices such as the mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) were determined by calculating their absolute values from the initially analysed blood parameters. Findings from this study suggest that methanolic extract of Ganoderma lucidum is safe and can be exploited in healthcare delivery systems