This study investigated the effect of Coriaria myrtifolia leaves by two behavioral tests intended to determine their anxiety and depression in rodents. The pharmacological test used for studying the anxiolytic effect was the light/dark exploration while the depression was measured with Forced test swimming (FTS). The methanolic extract of C myrtifolia, administered orally in mice at 20mg/kg, 40mg/kg and 100mg/kg produced a significant increase in the immobile response in the forced swimming test, affected spontaneous motor activity, also possesses depressive-like activity by decrease the time spent in the illuminated side of the light–dark test. These results provide support for the potential antipsychotic of C.myrtifolia, available to treat mania and psychotic disorder