The roots of Malachra capitata L. is used traditional Indian medicine to treat epilepsy. In present study the effect of aqueous extract of Malachra capitata L. (AMC) on antioxidant enzymes in rat brain after induction of epilepsy by MES and PTZ were observed. In which Superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase was significantly (P<0.01) decreased in rat brain due to epilepsy and it was significantly (P<0.01) restored by administration of aqueous extract of Malachra capitata L. treated rats. Similar dose dependent results were obtained in PTZ model also. Whereas AMC significantly decreased lipid peroxidation in both models. The anticonvulsant activity of AMC might be presents of antioxidant properties and it delays the generation of free radical in MES & PTZ induced epilepsy.